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The most radical solution was adopted by the company Intarcia, whose product Itca 650 comprises exenatide administered in an osmotic minipump the size of a match, and similar to those used for animals, but capable of providing a constant delivery of exenatide for 612 months after subcutaneous implantation (117)

10.1016/j.jep.2023.117386 108 HosseinzadehH.SadeghniaH

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The significant weight loss associated with these medications can alter bile composition, while effects on gastrointestinal hormones may influence gallbladder motility